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Generic One-alphaOne-alpha (Alfacalcidol 0.25/0.5 mcg)Alfacal (Macleods) Add to bookmarks What is a generic pill? Very often our web site visitors ask us about generic medications. In this section we have placed some useful information about generic pills in general and about the ones we have in our product list.
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Active component:

Alfacalcidol


Categories list: Gastrointestinal TractMuscle RelaxantsOsteoporosisSkin Care

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Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. Although alfacalcidol is widely used in the treatment of osteoporosis, its mechanism of action in bone is not fully understood. Alfacalcidol stimulates intestinal calcium (Ca) absorption, increases urinary Ca excretion and serum Ca levels, and suppresses parathyroid hormone (PTH) secretion.

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