Common Use

Xylocaine is a local anesthetic that works by blocking voltage-gated Na+ channels. This prevents the generation of impulses in sensory nerve endings and stops pain signals in nerve fibers. Its effects begin within 1-5 minutes after application to the skin or mucous membranes and typically last 30-60 minutes.

Xylocaine is used for:

• Topical anesthesia in dentistry, otorhinolaryngology, and gynecology
• Instrumental and endoscopic examinations
• Radiographic procedures
• Pain relief for burns, insect bites, contact dermatitis, and minor wounds

Dosage and Directions

Xylocaine gel is for topical use only. Apply a small amount to dry, clean skin as needed, 3-4 times daily.

Precautions

Use with caution in:

• Patients with hemorrhoidal bleeding
• Individuals with skin or mucous membrane trauma
• Elderly patients, children, and debilitated individuals
• Pregnant or breastfeeding women

Additional precautions:

• Avoid contact with eyes
• Be careful not to injure treated skin areas
• Avoid exposure to very hot or cold surfaces

Contraindications

Do not use Xylocaine if you have a known hypersensitivity to it or any of its components.

Possible Side Effects

Common adverse reactions may include:

• Allergic reactions (e.g., stinging, severe burning, skin sensitivity)
• Dizziness or drowsiness after application
• Swelling, redness, or unusual temperature sensations
• Bruising or purple skin discoloration

Serious side effects may include:

• Urethritis
• Headache or blurred vision
• Low blood pressure
• Bradycardia or arrhythmia
• Anxiety or agitation

Drug Interactions

The following drugs may interact with Xylocaine:

• Cimetidine and Propranolol: Increase Xylocaine blood levels, raising toxicity risk (may cause bradycardia, drowsiness, or stupor)
• Barbiturates, Phenytoin, Rifampin: Reduce Xylocaine effectiveness
• Antiarrhythmics (Aymalin, Amiodarone, Quinidine): May weaken heart contractions
• Beta-blockers: Increase bradycardia risk
• Procainamide: May lead to CNS excitation and hallucinations
• Sedatives/Hypnotics: Increase CNS depression
• MAO Inhibitors: May enhance anesthetic effects

Inform your doctor if you use:

• Mexiletine (Mexitil)
• Acetaminophen (Tylenol)
• Nitrates/Nitrites (Isordil, Monoket, Imdur)
• Phenobarbital (Solfoton, Luminal)
• Chloroquine (Aralen)
• Nitrofurantoin (Furadantin, Macrobid)
• Sulfa drugs (Septra, Bactrim, Gantanol)

Missed Dose

Xylocaine is used as needed, so there is no strict dosing schedule.

Overdose

Symptoms may include:

• Seizures
• Irregular heartbeat
• Slow or stopped breathing
• Respiratory failure
• Coma

Storage

Store at 15-30°C (59-86°F). Keep in a tightly sealed, light-resistant container away from moisture.

Disclaimer

This information is for general purposes only and does not cover all possible uses, interactions, or precautions. Do not use this for self-diagnosis or treatment. Always consult a healthcare professional before using Xylocaine or adjusting your treatment plan. We are not liable for any errors, omissions, or consequences resulting from the use of this information.