Common Use

Valproic acid is prescribed to treat convulsions, migraines, and bipolar disorder. While the exact mechanisms of its action are not fully understood, it is believed that Valproic acid increases levels of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain.

Dosage and Direction

Take Valproic acid exactly as prescribed by your doctor. Do not exceed the recommended dose. The initial dose for Valproate sodium intravenous injection is 10-15 mg/kg/day, divided into four doses and administered every six hours. The maintenance dose is 30 to 60 mg/kg/day, also divided into four doses and given every six hours. Use of Valproate sodium injection for more than two weeks has not been studied. Switch to oral Valproate products as soon as possible.

Precautions

Valproic acid may, in rare cases, cause life-threatening liver failure, particularly in children under two years old. The risk increases if the child is taking more than one seizure medication or has a brain disease causing mental impairment (e.g., multiple sclerosis, Creutzfeldt-Jacob disease, Huntington's disease, brain injury, or infection).

Valproic acid can also cause sudden, life-threatening pancreatitis, even after years of treatment. Seek immediate medical help if symptoms of early liver damage appear, such as stomach pain, nausea, vomiting, loss of appetite, dark urine, clay-colored stools, low fever, or jaundice.

Inform your doctor if you are pregnant or planning to become pregnant, as this medication may cause birth defects. Be aware that suicidal thoughts may occur during treatment. Notify your doctor if you experience changes in mood or behavior, such as depression, anxiety, hostility, hyperactivity, or thoughts of self-harm.

Contraindications

Valproic acid should not be administered to patients with a known hypersensitivity to the medication or those with urea cycle disorders.

Side Effects

Common side effects include headache, weakness, fever, nausea, vomiting, abdominal pain, diarrhea, loss of appetite, indigestion, constipation, drowsiness, tremors, dizziness, double vision, blurred vision, lack of coordination, abnormal eye movements, emotional instability, abnormal thinking, memory loss, flu-like symptoms, infections, bronchitis, runny nose, hair loss, and weight loss. Notify your doctor if these side effects become bothersome or worsen.

Drug Interaction

Certain medications, such as Phenytoin, Carbamazepine, and Phenobarbital (or Primidone), can reduce the concentration of Valproic acid in the blood. Inform your doctor about all prescribed and over-the-counter medications you are taking, including Aspirin, Felbamate, Carbapenem Antibiotics, Rifampin, Antacids (e.g., Maalox, Trisogel, Titralac), Chlorpromazine, Amitriptyline/Nortriptyline, Clonazepam, Diazepam, Ethosuximide, Lamotrigine, Tolbutamide, Topiramate, Warfarin, Zidovudine, and Lorazepam.

Missed Dose

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next one at the regular time. Do not double the dose or take extra medication.

Overdose

Symptoms of overdose include excessive drowsiness, heart block, and deep coma. Seek immediate medical attention if an overdose is suspected.

Storage

Store Valproic acid at room temperature between 20-25°C (68-77°F). Keep it away from moisture, heat, and sunlight. Avoid storing it in bathrooms or places accessible to children.

Disclaimer

The information provided here is general and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider or doctor for specific instructions tailored to your condition. We disclaim any responsibility for the reliability of this information or any errors it may contain. We are not liable for any direct, indirect, or consequential damages resulting from the use of this information or self-treatment.