Common Use

Oxcarbazepine is an antiepileptic drug used to treat seizure disorders (epilepsy). The exact mechanism of action of Oxcarbazepine and its active metabolite, 10-monohydroxy metabolite (MHD), is not fully understood. Oxcarbazepine works by blocking potential-dependent sodium channels, stabilizing overexcited neuronal membranes, inhibiting repetitive neuronal discharges, and reducing synaptic impulses. Its antiepileptic effects are also supported by increased potassium (K+) conductance and modulation of high-voltage-activated calcium (Ca2+) channels. While primarily used for epilepsy, Oxcarbazepine may also be prescribed in rare cases for the treatment of bipolar disorder (manic-depressive disorder).

Dosage and Direction

Oxcarbazepine is available in tablet and oral suspension (liquid) forms. It is typically taken every 12 hours, with or without food. Consistent timing is important to maintain stable medication levels in the bloodstream. Before using the suspension, shake it thoroughly to ensure an even mixture. Do not abruptly stop taking Oxcarbazepine without consulting your doctor, as this may worsen seizures.

Precautions

Inform your healthcare provider if you have a known allergy to oxcarbazepine, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), or any other medications. Disclose all medications and herbal products you are currently taking. Notify your doctor if you have or have had kidney or liver disease, are pregnant, planning to become pregnant, or are breastfeeding. Oxcarbazepine may cause drowsiness, dizziness, changes in mental health, or suicidal thoughts.

Contraindications

• Hypersensitivity to oxcarbazepine or its components.
• Breastfeeding.

Caution is advised for patients with a history of hypersensitivity to carbamazepine or during pregnancy. The safety and efficacy of Oxcarbazepine in children under 2 years of age have not been established.

Possible Side Effects

Seek immediate medical attention if you experience any of the following severe symptoms:

• Dizziness, drowsiness, or vision changes.
• Involuntary, rapid, repetitive eye movements.
• Diarrhea, constipation, heartburn, abdominal pain, or loss of appetite.
• Dry mouth, unstable gait, or uncontrollable body tremors.
• Coordination disorders, slowed movements, or difficulty concentrating.
• Tooth or ear pain, sweating, hot flashes, or nosebleeds.
• Signs of an allergic reaction, such as swelling, redness, irritation, or burning.

Call your doctor immediately if you experience:

• Swelling of the face, throat, tongue, or lips.
• Unusually long or frequent seizures.
• Headache, nausea, vomiting, or confusion.
• Red or purple-colored blotches or dots on the skin.
• Jaundice, unusual bruising, or bleeding.
• Bleeding or tarry stools, joint pain, or chest pain.

Drug Interactions

The following medications may interact with Oxcarbazepine:

• Amiodarone (Cordarone).
• Amitriptyline (Elavil).
• Calcium channel blockers, such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), and others.
• Chlorpromazine (Thorazine).
• Clomipramine (Anafranil).
• Cyclophosphamide (Cytoxan, Neosar).
• Desmopressin (DDAVP, Minirin, Stimate).
• Diazepam (Valium).
• Diuretics ('water pills').
• Hormonal contraceptives (birth control pills, rings, patches, etc.).
• Indapamide (Natrilix).
• Other antiepileptic drugs, such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenobarbital, phenytoin (Dilantin), and valproic acid (Depakene, Depakote).
• Proton-pump inhibitors, such as lansoprazole (Prevacid), omeprazole (Prilosec), and pantoprazole (Protonix).
• Theophylline (Theo-Dur).
• Selective serotonin reuptake inhibitors (SSRIs), such as citalopram (Celexa), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil), fluoxetine (Prozac, Sarafem), duloxetine (Cymbalta), and sertraline (Zoloft).

Missed Dose

If you miss a dose, consult your doctor for guidance on when to take the next dose.

Overdose

In case of an overdose, contact your healthcare provider immediately. Symptoms may include a worsening of side effects.

Storage

Store Oxcarbazepine at room temperature, away from excessive heat and moisture. Do not use the medication after the expiration date.

Disclaimer

The information provided here is general and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider or doctor for specific instructions tailored to your condition. We disclaim any liability for the reliability of this information or potential errors. We are not responsible for any direct, indirect, or consequential damages resulting from the use of this information or self-treatment.