Common Use

Tiova is a long-acting muscarinic receptor antagonist designed to treat respiratory conditions. It specifically targets and reversibly blocks M3 receptors in the respiratory tract, leading to the relaxation of smooth muscles in the bronchial tree. The drug's high receptor affinity and slow release from the M3 receptor complex ensure prolonged local action. Tiova's bronchodilatory effect is dose-dependent and lasts for at least 24 hours. It is primarily used to manage bronchial spasms (wheezing) associated with chronic obstructive pulmonary disease (COPD), chronic bronchitis, and emphysema.

Dosage and Direction

Tiova is available as capsules containing powder for inhalation, to be used with the HandiHaler device. It is recommended to take the medication at the same time each day for optimal results.

Precautions

• Exercise caution in patients with narrow-angle glaucoma or urination disorders caused by prostatic hypertrophy or bladder neck obstruction.
• Tiova is not intended for emergency relief of bronchial spasms.
• Avoid contact with the eyes.
• Regular monitoring is required for patients with moderate to severe renal failure, especially if they are taking medications excreted by the kidneys.
• Inhaled medications may cause paradoxical bronchospasm or similar reactions.
• Avoid use during pregnancy or breastfeeding.

Contraindications

• Tiova is contraindicated in patients with hypersensitivity to the drug, atropine, or its derivatives (e.g., ipratropium, oxytropine).
• Its use in adolescents under 18 years of age has not been studied.

Possible Side Effects

• Common side effects include dry mouth, throat pain, coughing, and paradoxical bronchospasm.
• If the medication comes into contact with the eyes, temporary changes in accommodation may occur.
• Allergic reactions such as rash or swelling are possible.
• Rare cases may include rapid heartbeat, acute glaucoma, difficulty urinating in men with prostatic hypertrophy, or constipation.

Drug Interactions

Concurrent use of Tiova with other anticholinergic medications is not recommended.

Missed Dose

If a dose is missed, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose. Do not double the dose. Maintain a consistent schedule to avoid missing doses.

Overdose

No cases of overdose have been reported when Tiova is used at therapeutic doses. Excessive dosing may lead to anticholinergic symptoms such as temporary changes in accommodation and dry mouth. Acute poisoning is unlikely due to the drug's low bioavailability when inhaled.

Storage

Store Tiova at room temperature, away from moisture, sunlight, children, and pets. Keep it in a tightly sealed container.

Disclaimer

This information provides a general overview of Tiova and does not cover all possible instructions, drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider or doctor for specific guidance. We are not responsible for any direct, indirect, or consequential damages resulting from the use of this information or self-treatment practices.