Common Use

Tinidazole is an antiprotozoal and antibiotic medication used to treat certain infections caused by protozoa or infections in the vagina. It effectively kills sensitive parasites and bacteria and is also used to treat specific sexually transmitted infections.

Dosage and Direction

Take Tinidazole orally with food or milk for best results. It is recommended to take it at the same time each day.

Dosage for Children 3 Years and Older:

• Amebiasis, intestinal: 50 mg/kg/day for 3 days (up to 2 g/day)
• Amebiasis, liver abscess: 50 mg/kg/day for 3-5 days (up to 2 g/day)
• Giardiasis: 50 mg/kg as a single dose (up to 2 g/day)

Dosage for Adults:

• Amebiasis, intestinal: 2 g/day for 3 days
• Amebiasis, liver abscess: 2 g/day for 3-5 days
• Bacterial vaginosis: 2 g/day for 2 days or 1 g/day for 5 days
• Giardiasis: 2 g as a single dose
• Trichomoniasis: 2 g as a single dose. For best results, ensure your sexual partner is treated simultaneously with the same dose.

Note: This guidance is for informational purposes only. Always consult your doctor before use for optimal results.

Precautions

Avoid alcohol while taking Tinidazole and for 3 days after stopping. Combining alcohol with Tinidazole may cause stomach cramps, nausea, vomiting, headaches, and flushing. Use cautiously if you have a history of seizure disorders, hepatic impairment, or renal impairment. If treating trichomoniasis, ensure your sexual partner is treated simultaneously, even if asymptomatic. Avoid Tinidazole during pregnancy, while planning pregnancy, or while breastfeeding without medical advice.

Contraindications

Tinidazole is contraindicated in individuals hypersensitive to tinidazole, nitroimidazole derivatives (including metronidazole), or any component of the medication. It is also contraindicated during the first trimester of pregnancy and for breastfeeding mothers.

Possible Side Effects

Side effects may include allergic reactions. Common side effects include:

• Seizures
• Fever, chills, body aches, flu symptoms
• Numbness, burning, pain, or tingling sensations
• Severe blistering, peeling, or red skin rash with fever, sore throat, and headache

Less serious side effects include:

• Vaginal yeast infection (itching, white discharge)
• Unpleasant metallic taste in the mouth
• Nausea, vomiting, loss of appetite, indigestion
• Constipation, diarrhea, stomach cramps
• Dark-colored urine
• Headache, dizziness
• Muscle or joint pain
• Dry mouth, thirst, tongue discoloration
• White patches or sores in the mouth or on the lips
• Minor skin rash or itching

Discontinue use and consult your doctor immediately if you experience severe side effects. Report any unusual symptoms to your healthcare provider.

Drug Interactions

Tinidazole may interact with:

• Amiodarone
• Cimetidine
• Cholestyramine
• Cyclosporine or tacrolimus
• Dexamethasone
• Fluorouracil
• Griseofulvin
• Lithium
• Rifampin
• St. John's wort
• Antibiotics such as azithromycin, ciprofloxacin, clarithromycin, erythromycin, itraconazole, or ketoconazole
• HIV medications, including nevirapine, delavirdine, or efavirenz
• Seizure medications such as carbamazepine, phenytoin, or phenobarbital

Drug interactions may alter the effectiveness of medications. Consult your doctor to manage interactions appropriately.

Missed Dose

If you miss a dose, take it as soon as remembered. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Overdose

Symptoms of overdose are unknown. Seek immediate medical attention if you experience unusual symptoms.

Storage

Store Tinidazole at room temperature, between 20-25°C (68-77°F).

Disclaimer

This information provides general guidance about medications and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions. We disclaim responsibility for any errors or omissions in this information and any consequences of self-treatment.