Common Use

Tadarise is a highly effective and reversible selective inhibitor of phosphodiesterase type 5 (PDE 5) that specifically targets cyclic guanosine monophosphate (cGMP). It contains Tadalafil as its active ingredient. During sexual stimulation, Tadalafil inhibits PDE 5, leading to an increase in cGMP levels in the penile cavernous body. This results in the relaxation of arterial smooth muscles, enhancing blood flow to the penile tissues and facilitating erections. Tadalafil only works in the presence of sexual stimulation. It improves erections and enables successful sexual intercourse. The effects of Tadalafil can last up to 36 hours, with the onset of action occurring as quickly as 16 minutes after consumption.

Dosage and Direction

Sublingual Tadalafil is administered by placing it under the tongue. The recommended dose is 20 mg, which should be taken at least 16 minutes before sexual activity. The effects can persist for up to 36 hours. It is important to take Tadalafil only once daily and not exceed the recommended dosage.

Precautions

Avoid consuming grapefruit juice, alcoholic beverages, or tobacco while using Tadalafil. Combining Tadalafil with tobacco may lead to a condition called NAION (sudden optic nerve-related vision loss). Inform your doctor if you have any of the following conditions:

• Abnormal penile structure, including a curved penis or congenital defects
• History of coronary artery disease, arrhythmia, angina, heart attack, or heart failure
• Hypotension or hypertension
• Bleeding disorders or stomach ulcers
• Diabetes or hyperlipidemia (excess lipids in the blood)
• Sickle-cell anemia
• Liver or kidney failure

Contraindications

Tadalafil is contraindicated in patients who use organic nitrates, either regularly or intermittently, as it can amplify the hypotensive effects of nitrates.

Possible Side Effects

Common side effects of Tadalafil include facial flushing, headaches, stomach upset, diarrhea, flu-like symptoms, and nausea. In rare cases, the following may occur:

• Low blood pressure
• Blurred or altered color vision
• Abnormal ejaculation
• Prolonged erections or priapism (painful erections lasting more than 6 hours)

If an erection lasts longer than 4 hours, seek immediate medical attention to prevent permanent damage. Tadalafil may also exacerbate heart problems in individuals with pre-existing heart conditions.

Drug Interactions

Avoid using Tadalafil with medications containing organic nitrates, as this can lead to severe hypotension. Medications to avoid include:

• Erythrityl Tetranitrate
• Isosorbide Dinitrate
• Isosorbide Mononitrate
• Nitroglycerin
• Pentaerythritol Tetranitrate

Drugs such as erythromycin, ketoconazole, itraconazole, indinavir, and ritonavir can increase Tadalafil levels and toxicity. Inform your doctor if you are taking:

• Atazanavir, Bunazosin, Clarithromycin, Doxazosin
• Indinavir, Itraconazole, Ketoconazole, Moxisylyte
• Nefazodone, Nelfinavir, Phenoxybenzamine, Phentolamine
• Prazosin, Saquinavir, Telithromycin, Terazosin
• Trimazosin, Urapidil

Missed Dose

Since Tadalafil is used as needed for treating erectile dysfunction, a missed dose is not applicable.

Overdose

An overdose of Tadalafil may cause symptoms similar to its side effects. Seek immediate medical attention if you suspect you have taken too much of this medication.

Storage

Store Tadalafil at room temperature, away from moisture, sunlight, children, and pets. Keep it in a tightly sealed container.

Disclaimer

The information provided here offers general guidance about medications and does not cover all possible directions, drug interactions, or precautions. This content should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions tailored to your condition. We disclaim any responsibility for the reliability of this information or any errors it may contain. We are not liable for any direct, indirect, special, or consequential damages resulting from the use of this information or the consequences of self-treatment.