Common use

Tacrolimus is an immunosuppressive medication used to prevent organ rejection in transplant patients, particularly after kidney, liver, or heart transplants. It works by inhibiting calcineurin, an enzyme crucial for activating T-cells in the immune system. By suppressing immune activity, tacrolimus helps the body accept a transplanted organ.

Dosage and direction

Tacrolimus is available in three forms:

• Oral capsules
• Extended-release tablets
• Intravenous forms

Dosage is highly individualized based on:

• Patient weight
• Organ type
• Blood levels

It is typically taken twice daily, 12 hours apart, on an empty stomach at the same time each day to maintain consistent blood levels.

Precautions

Key precautions for tacrolimus use include:

• Regular blood tests to monitor kidney function and drug levels
• Avoiding grapefruit or grapefruit juice (increases drug concentration)

Extra caution is needed for patients with:

• Liver or kidney disease
• Diabetes
• Electrolyte imbalances

Contraindications

Tacrolimus should not be used by:

• Patients with hypersensitivity to tacrolimus or macrolide antibiotics
• Those who cannot be closely monitored
• Patients taking drugs that severely interfere with its metabolism

Pregnant or breastfeeding women should consult their doctor about potential risks.

Possible side effects

Common side effects include:

• Tremors
• Headache
• Nausea
• High blood sugar
• Kidney dysfunction

Long-term use risks include:

• Increased infection risk
• High blood pressure
• Certain cancers (including lymphoma)

Report any unusual symptoms to your healthcare provider immediately.

Drug interactions

Tacrolimus interacts with many medications:

• Antifungals (ketoconazole)
• Antibiotics (erythromycin)
• Anticonvulsants (phenytoin)

These interactions can either increase or decrease tacrolimus levels. Inform your doctor about all medications and supplements, including herbal products like St. John's Wort.

Missed dose

If you miss a dose:

• Take it as soon as remembered unless close to next dose
• Never double up or take extra medication
• Missed doses increase rejection risk

Overdose

Overdose symptoms may include:

• Kidney failure
• Seizures
• Extreme immune suppression

Seek immediate medical help for suspected overdose. Treatment requires supportive care in a medical facility.

Storage

Proper storage guidelines:

• Store at room temperature
• Keep away from moisture, heat and direct light
• Keep capsules in original packaging
• Do not freeze
• Keep out of reach of children

Short description

Tacrolimus is a powerful immunosuppressant used to prevent organ rejection following transplantation. It works by blocking immune responses that could attack the new organ. Available in oral and injectable forms, it requires careful monitoring of blood levels and kidney function. Due to potential side effects, it should be used exactly as prescribed.

Important Disclaimer

This information provides general medication guidelines only and does not cover all possible directions, drug interactions, or precautions. This content should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for patient-specific instructions. We cannot guarantee the accuracy of this information and are not responsible for any consequences resulting from its use or from self-treatment.