Common Use

Sotalol contains sotalol hydrochloride. It is an antiarrhythmic drug which possesses properties of classes II (beta-adrenoreceptor blocking) and III (cardiac action potential duration prolongation). Sotalol is used to treat many forms of supraventricular arrhythmias, and in particular it has advantage over other beta-blockers in treatment of:

• Atrial fibrillation (chaotic contractions)
• Atrial flutter (frequent rhythmic constructions)
• Supraventricular tachycardia (heart rhythm disorder)
• Wolff-Parkinson-White syndrome (congenital heart disease characterized by recurrent disorders of heart rhythm and rate)
• Paroxysmal form of atrial fluttering
• Ventricular tachycardia

Dosage and Direction

• The recommended starting dose is 0.04-0.08 g taken 2-3 times daily
• If necessary the dose may be increased up to 0.16 g taken 2-3 times daily
• Take it orally with a full glass of water before a meal
• Do not chew the medication

Precautions

Sotalol should be used with cautiousness in the patients with recent myocardial infarction. Limit intake of alcoholic beverages. Discuss with your doctor if you have:

• Bronchitis or emphysema
• A heart disease or congestive heart failure in history
• Diabetes
• Kidney disease
• A thyroid disorder
• A recent heart attack

Contraindications

Sotalol should not be used in patients with:

• Chronic heart failure
• Cardiogenic shock
• Atrioventricular block (disorders of conduction of excitation in conduction system of the heart)
• Arterial hypotension (low blood pressure)
• Sick sinus syndrome
• Bradycardia
• Elongated QT interval on the electrocardiogram
• Hypokalemia (decreased potassium levels in the blood)
• Obliterative artery diseases
• Obstructive pulmonary disease
• Metabolic acidosis
• Hypersensitivity to the components of the drug

Caution must be exercised in the appointment of sotalol patients with recent myocardial infarction.

Possible Side Effects

Side effects of Sotalol are associated with its property to block beta-adrenoreceptors. Sinus bradycardia (rare heart rate) was reported in 9-11% of patients together with symptoms of heart failure. You may experience these effects:

• Lightheadedness
• Headache
• Drowsiness
• Dizziness
• Stomach upset
• Blurred vision
• Cough
• Trouble sleeping
• Reduced concentration
• Dry skin
• Decreased sexual desire
• Altered taste
• Muscle aches

Notify your doctor if the adverse reactions listed above and also if the following adverse reactions aggravate:

• Mental confusion
• Trouble urinating
• Easy bruising or bleeding
• Chest pain
• Skin rash
• Sore throat
• Breathing trouble
• Fainting
• Irregular heartbeat

Drug Interactions

Inform your doctor about all prescribed and over-the-counter medicines and herbal products you are taking and especially about:

• Medication for blood pressure (clonidine)
• Antacids
• St John's wort
• Anti-diabetic drugs
• Calcium channel blockers (verapamil, diltiazem)
• Arbutamine
• Aspirin/NSAIDS (ibuprofen, naproxen)
• Drugs which may change heart rhythm such as "water pills" (diuretics such as furosemide or hydrochlorothiazide)
• Quinidine
• Procainamide
• Sparfloxacin
• Dofetilide
• Pimozide

Follow all directions of your doctor and avoid taking medication for allergies or cough or colds without his permission.

Missed Dose

• Never take a double dose of this medication
• If it is almost time of the next dose just skip the missed portion
• Continue to take the medicine according to the schedule

Overdose

Symptoms of overdose may include:

• Chest pain
• Swelling
• Hunger
• Slow or fast heartbeats
• Shortness of breath
• Weakness
• Confusion
• Seizure
• Sweating
• Feeling light-headed
• Fainting

Storage

Sotalol should be stored at room temperature between 15-30 C (59-86 F).

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.