Common Use

The main component of the antiviral drug Rebetol is Ribavirin. It is used in combination with interferon drugs such as Intron A or PEG-Intron to treat chronic hepatitis C. Rebetol works by inhibiting the replication of new virions and selectively blocking the synthesis of viral RNA without affecting RNA synthesis in normal cells. It is most effective against:

• Herpes simplex virus
• Smallpox virus
• Influenza viruses A and B
• Paramyxovirus (parainfluenza, mumps, Newcastle disease)
• Reovirus
• Oncogenic RNA viruses

Dosage and Direction

Ensure you drink plenty of water while taking Rebetol, especially during the initial stages of treatment. The treatment typically lasts between 24 to 48 weeks. For hepatitis C, take Rebetol orally with food and a full glass of water. Do not chew the tablet; swallow it whole. The recommended dose is 1-1.2 grams per day, divided into two doses taken in the morning and evening.

Precautions

Rebetol may pose significant risks to developing infants and can cause abnormalities in sperm. It is crucial to use effective contraception during treatment and for at least six months afterward. At least two forms of birth control are recommended.

Contraindications

Rebetol is contraindicated in:

• Patients hypersensitive to any components of Rebetol
• Pregnant or breastfeeding women
• Patients with chronic heart failure, myocardial infarction, kidney or liver failure, severe anemia, decompensated cirrhosis, autoimmune diseases, or incurable thyroid disease
• Patients with severe depression or suicidal tendencies
• Children and adolescents under 18 years of age

Caution is advised for patients with decompensated diabetes mellitus, pulmonary embolism, heart failure, thyroid disease, impaired clotting, thrombophlebitis, myelosuppression, hemoglobinopathy, depression, or a history of suicidality.

Possible Side Effects

The most serious adverse reaction to Rebetol is anemia. Other potential side effects include:

• Blood disorders
• Fever
• Hair loss
• Depression
• Fatigue
• Headache
• Insomnia
• Irritability
• Nausea
• Shortness of breath
• Joint or muscle pain
• Weight loss

Contact your doctor immediately if you experience any severe side effects.

Drug Interactions

Concomitant use of Rebetol with other antiviral drugs like zidovudine (Retrovir), zalcitabine (Hivid), or stavudine (Zerit) may lead to lactic acidosis. Medications containing Mg2+ or Al3+, as well as simethicone, can decrease the absorption of Retrovir. Rebetol may suppress the effects of zidovudine. In HIV patients, combining Rebetol with zidovudine and stavudine may result in HIV viremia, necessitating a change in treatment.

Missed Dose

Do not take a double dose if you miss one. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

Overdose

If you suspect an overdose, seek immediate medical attention. There is limited information on the adverse effects of Rebetol overdose.

Storage

Store Rebetol at room temperature, between 2-8°C (36-46°F).

Disclaimer

This information provides a general overview and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions. We disclaim the reliability of this information and any errors it may contain. We are not responsible for any direct, indirect, special, or consequential damages resulting from the use of this information or self-treatment.