Common Use

Progesterone is a female hormone (progestin) similar to the progesterone naturally produced by your body. It is prescribed to replace this hormone when your body does not produce enough. In non-pregnant women who are not undergoing menopause, this medication helps restore normal menstrual periods that have stopped for several months (amenorrhea).

Progesterone is also used in combination with estrogen in hormone replacement therapy to alleviate menopause symptoms, such as hot flashes. It is added to estrogen therapy to lower the risk of uterine cancer.

Dosage and Direction

Take progesterone by mouth, typically once daily at bedtime or as directed by your doctor. If you have difficulty swallowing the pills, take them with a full glass of water while standing. Follow the dosing schedule carefully and consult your doctor if you have questions. The dosage depends on your medical condition and response to treatment.

Precautions

Before taking progesterone, inform your doctor or pharmacist if you are allergic to it, peanuts, or have other allergies. Discuss your medical history, especially if you have:

• History of blood clots
• History of brain bleeding
• Liver disease
• Breast cancer or other female organ cancers
• Unexplained vaginal bleeding
• Loss of pregnancy with remaining tissue in the uterus ("missed abortion")
• Recent stroke or heart attack (within 1 year)

Avoid prolonged sun exposure, tanning booths, and sunlamps. Use sunscreen and wear protective clothing outdoors.

Contraindications

Do not drive, operate machinery, or perform activities requiring alertness until you are sure you can do so safely. Limit alcohol consumption and avoid smoking. Use this medication during pregnancy only as directed by your doctor. Discuss the risks and benefits of progestins with your doctor, as there is conflicting information about their effects on unborn babies.

This drug passes into breast milk. Consult your doctor before breastfeeding.

Possible Side Effects

Common side effects may include:

• Nausea
• Bloating
• Breast tenderness
• Headache
• Change in vaginal discharge
• Mood swings
• Blurred vision
• Dizziness or drowsiness

If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Most people using this medication do not experience serious side effects.

Drug Interaction

Before using progesterone, inform your doctor or pharmacist of all prescription and non-prescription/herbal products you use, especially:

• Drugs affecting liver enzymes that process progesterone (e.g., rifampin, St. John's wort, azole antifungals like itraconazole, certain anti-seizure medications like carbamazepine, phenobarbital, or phenytoin)

Missed Dose

If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Overdose

Suspect an overdose? Contact your local poison control center or emergency room immediately. Symptoms may include severe nausea and vomiting. Seek medical advice for further details.

Storage

Store progesterone at room temperature (77°F or 25°C), away from light and moisture. Brief storage between 59-86°F (15-30°C) is permitted. Avoid storing in the bathroom. Keep all medications out of reach of children and pets.

Disclaimer

This information provides a general overview of medications and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions tailored to your condition. We disclaim responsibility for the reliability of this information or any errors it may contain. We are not liable for any direct, indirect, or special damages resulting from the use of this information or consequences of self-treatment.