Common Use

Procoralan (ivabradine) is primarily prescribed for chronic stable angina and heart failure with reduced ejection fraction. It reduces symptoms such as chest pain and fatigue by slowing the heart rate and is often used when beta‑blockers are not tolerated or need to be combined.

Dosage and Direction

The typical adult dose is 5–7.5 mg taken twice daily with meals. A physician may adjust the dose based on heart‑rate response. Take the medication at the same times each day and do not stop it abruptly without medical advice.

1. Take with meals
2. Maintain a consistent dosing schedule
3. Do not discontinue without consulting a healthcare provider

Precautions

Before starting Procoralan, inform your doctor if you have low blood pressure, bradycardia, sick‑sinus syndrome, or liver disease. Regular monitoring of heart rate is recommended, and you should avoid grapefruit and alcohol as they may affect the drug's action.

• Report history of low blood pressure or bradycardia
• Monitor heart rate regularly
• Avoid grapefruit and alcohol

Contraindications

Do not use Procoralan if you have severe bradycardia, acute heart failure, cardiogenic shock, or severe hypotension. It is also contraindicated in patients with sick‑sinus syndrome, sinus‑atrial block, or hypersensitivity to ivabradine.

• Severe bradycardia
• Acute heart failure
• Cardiogenic shock
• Severe hypotension
• Sick‑sinus syndrome
• Sino‑atrial block
• Hypersensitivity to ivabradine

Possible Side Effects

Common side effects include bradycardia, dizziness, fatigue, and visual disturbances such as phosphenes. Severe reactions may involve heart‑rhythm abnormalities or fainting. Contact a healthcare professional if you experience unusual symptoms.

• Bradycardia (slow heart rate)
• Dizziness
• Fatigue
• Visual disturbances (phosphenes)
• Heart rhythm abnormalities
• Fainting

Drug Interaction

Procoralan can interact with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) or inducers, affecting drug levels. Combining it with other heart‑rate‑lowering medications may increase the risk of bradycardia. Always disclose all medications and supplements to your doctor.

• Strong CYP3A4 inhibitors (ketoconazole, clarithromycin)
• CYP3A4 inducers
• Other heart‑rate‑lowering drugs

Missed Dose

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Overdose

Overdose may cause severe bradycardia, hypotension, or heart‑rhythm disturbances. Seek immediate medical attention if an overdose is suspected. Emergency treatment typically involves heart‑function monitoring and supportive care.

Storage

Store Procoralan at room temperature, away from moisture and direct sunlight. Keep the medication out of reach of children and do not use it past its expiration date.

Disclaimer

This information provides general guidance about Procoralan and does not replace professional medical advice. Dosage, drug interactions, and precautions may vary by individual. Always follow the instructions of your healthcare provider and consult them before making any changes to your medication regimen.