Common Use

Prandin contains the active component Repaglinide, which stimulates insulin secretion from the pancreas. It is used to treat type 2 diabetes mellitus, typically in combination with diet therapy, physical activity, and sometimes alongside metformin.

Dosage and Direction

Take Prandin orally 15-30 minutes before meals, usually three times a day. Dosage is individualized, with an initial recommended dose of 0.5 mg. The dose may be increased after 1-2 weeks if blood glucose levels require it. The maximum single dose is 4 mg, and the maximum daily dose is 16 mg. For patients switching from other oral diabetes medications, the initial recommended dose is 1 mg.

Precautions

Inform your doctor or pharmacist if you have liver or kidney impairments. Use Prandin cautiously in weakened patients or those scheduled for major surgery.

Contraindications

Prandin should not be used if you have:

• Hypersensitivity to its components
• Type 1 diabetes mellitus
• Diabetic ketoacidosis (with or without coma)
• Severe liver or kidney disease
• Pregnancy or breastfeeding

It is also not recommended for children or patients older than 75 years.

Side Effects

Possible side effects include:

• Hypoglycemia
• Visual acuity loss
• Dyspepsia
• Transient increase in liver enzymes
• Allergic reactions

Drug Interactions

Prandin may interact with:

• Beta-blockers
• Chloramphenicol
• Indirect anticoagulants (coumarin derivatives)
• NSAIDs
• Probenecid
• Salicylates
• MAO inhibitors
• Sulfonamides
• Alcohol
• Anabolic steroids
• Calcium channel blockers
• Corticosteroids
• Diuretics (especially thiazides)
• Isoniazid
• Niacin
• Oral contraceptives
• Phenothiazines
• Phenytoin
• Sympathomimetics
• Thyroid hormones

Some drugs, like erythromycin, ketoconazole, and miconazole, slow down Prandin's metabolism, while barbiturates, carbamazepine, and rifampin speed it up.

Missed Dose

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and return to your regular schedule. Do not double the dose to make up for the missed one.

Overdose

Symptoms of overdose include hypoglycemia, which may cause:

• Hunger
• Fatigue and weakness
• Headache
• Irritability
• Anxiety
• Drowsiness
• Restless sleep or nightmares
• Behavioral changes
• Poor concentration
• Slurred speech
• Vision problems
• Confusion
• Pallor
• Nausea
• Palpitations
• Cramps
• Cold sweats
• Coma

Storage

Store Prandin at room temperature (20-25°C or 68-77°F). Keep it away from moisture, heat, and sunlight. Avoid storing it in the bathroom or places accessible to children.

Disclaimer

The information provided here is general and does not cover all directions, drug interactions, or precautions. It is not a substitute for professional medical advice. Always consult your healthcare provider for specific instructions. We do not guarantee the accuracy or reliability of this information and are not responsible for any consequences of self-treatment.