Common Use

Pepcid is an H2-histamine receptor blocker that reduces basal and stimulated production of gastric hydrochloric acid (HCl). It also decreases pepsin activity alongside HCl reduction. Pepcid enhances the protective mechanisms of the stomach's mucous layer by stimulating the production of glycoprotein-rich mucus. Other H2 blockers include cimetidine (Tagamet), ranitidine (Zantac), and nizatidine (Axid).

Pepcid is prescribed for conditions such as stomach and duodenal ulcers, hyperacidity, heartburn, stress-related gastrointestinal ulcers, erosive reflux esophagitis, gastropathy induced by non-steroidal anti-inflammatory drugs (NSAIDs), and Zollinger-Ellison syndrome.

Dosage and Directions

The recommended dose of Pepcid for duodenal ulcers is 40 mg once daily at bedtime or 20 mg twice daily. Treatment typically takes about 4 hours. Always follow your physician's instructions. Do not exceed the prescribed dose. Chew the tablet before swallowing. For the liquid form, shake it well for 10-20 seconds, measure with a special spoon, and take it before meals.

Precautions

Avoid Pepcid if you are allergic to it or other H2 blockers. Inform your doctor if you have kidney or liver disease, stomach cancer, asthma, chronic obstructive pulmonary disease, or other breathing issues. Pregnant, planning to become pregnant, or breastfeeding individuals should consult their doctor before use. Avoid alcohol during treatment.

Contraindications

Pepcid is contraindicated in cases of hypersensitivity, pregnancy, and breastfeeding. Use with caution in patients with liver or kidney failure, cirrhosis, or infants.

Possible Side Effects

Common side effects include allergy symptoms, constipation, diarrhea, fatigue, headache, insomnia, muscle pain, nausea, and vomiting. Serious side effects may include agitation, anemia, confusion, depression, easy bruising or bleeding, hallucinations, hair loss, irregular heartbeat, rash, visual changes, and jaundice.

Drug Interaction

Pepcid reduces the metabolism of medications like phenazone, diazepam, propranolol, and others in the liver. It increases the absorption of amoxicillin and clavulanic acid. Antacids and sucralfate slow its absorption, while it reduces the absorption of itraconazole and ketoconazole.

Missed Dose

Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to compensate.

Overdose

Symptoms of Pepcid overdose include nausea, vomiting, diarrhea, stomach pain, rapid heart rate, or fainting. Seek immediate medical attention if an overdose is suspected.

Storage

Store Pepcid at room temperature (15-30°C or 59-86°F), away from light and moisture, and out of reach of children and pets. For injections, store between 2-8°C (36-46°F).

Disclaimer

This information provides a general overview of Pepcid and does not cover all directions, drug interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider for personalized advice. We disclaim responsibility for any errors in this information or damages resulting from its use.