Common Use

Orap (pimozide) is prescribed to treat severe motor and vocal tics in patients with Tourette's disorder when other treatments have not been effective. It works by blocking dopamine receptors in the brain, helping to reduce involuntary movements and vocalizations.

Dosage and Direction

Orap is taken orally, usually once daily or as prescribed. The medication can be taken with or without food and should be taken with water. Any dose adjustments must be made only by a healthcare provider because Orap is closely monitored for its effects on the heart and nervous system.

Precautions

Before taking Orap, inform your doctor if you have heart problems, a family history of sudden cardiac death, electrolyte imbalances, liver disease, or a history of seizures. Regular electrocardiogram (ECG) monitoring may be required. Avoid alcohol and use caution when performing activities that require alertness. Do not stop the medication abruptly without medical advice.

Contraindications

Do not use Orap if you are allergic to pimozide or similar medications. It is contraindicated in patients with known QT prolongation, arrhythmias, severe electrolyte imbalances, or those taking certain medications that affect heart rhythm. It should not be used together with strong CYP3A4 inhibitors.

Possible Side Effects

Common side effects include drowsiness, dizziness, dry mouth, constipation, blurred vision, or restlessness. Serious side effects may include heart rhythm abnormalities, uncontrolled muscle movements, severe stiffness, tremors, or signs of neuroleptic malignant syndrome. Seek immediate medical attention if severe symptoms occur.

Drug Interactions

Orap interacts with many medications, including antidepressants, antipsychotics, antibiotics, antifungals, antiarrhythmics, and drugs that affect electrolyte balance. Grapefruit products may also interact. Always inform your doctor about all medications and supplements you are taking.

Missed Dose

If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Skip the missed dose if needed - do not double the dose.

Overdose

Overdose symptoms may include severe drowsiness, confusion, tremors, seizures, or dangerous heart rhythm changes. Seek emergency medical attention immediately.

Storage

• Store Orap at room temperature, away from moisture, heat, and light.
• Keep the medication in its original container and out of reach of children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on this site cannot be used for self‑treatment or self‑diagnosis. Any specific instructions for a particular patient should be agreed with your health‑care adviser or doctor in charge of the case. We disclaim reliability of this information and any errors it may contain. We are not responsible for any direct, indirect, special, or other indirect damage resulting from the use of the information on this site or from self‑treatment.