Common Use

Nintedanib is a tyrosine kinase inhibitor used to treat idiopathic pulmonary fibrosis (IPF), chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, and systemic sclerosis-associated ILD. It works by blocking specific enzymes involved in the scarring (fibrosis) process in the lungs. This helps slow the progression of lung damage and preserves respiratory function over time. Nintedanib does not cure these diseases but can help manage symptoms and disease progression.

Dosage and Direction

The standard dose of nintedanib for adults is 150 mg taken twice daily, approximately 12 hours apart, with food to reduce stomach upset. Dosage may be reduced to 100 mg twice daily in case of intolerable side effects.

• Capsules should be swallowed whole
• Do not chew or crush capsules
• Follow the prescribed schedule exactly
• Consult your doctor before making any changes

Precautions

Nintedanib requires special precautions for safe use:

• May increase risk of bleeding and liver enzyme elevation
• Can cause gastrointestinal problems such as diarrhea
• Regular liver function tests are recommended
• Use caution in patients with cardiovascular disease or hepatic impairment
• Exercise caution with concurrent anticoagulant use
• Pregnant women should avoid use due to fetal risk

Contraindications

Nintedanib should not be used in certain situations:

• Known hypersensitivity to nintedanib or its components
• Pregnancy (risk of fetal harm)
• Severe liver impairment (Child-Pugh C)
• Not recommended for children or adolescents under 18 years

Possible Side Effects

Common side effects of nintedanib include:

• Diarrhea (most common)
• Nausea and vomiting
• Elevated liver enzymes
• Abdominal pain
• Decreased appetite

Serious but rare side effects require immediate medical attention:

• Arterial thromboembolic events
• GI perforation
• Bleeding complications

Drug Interactions

Important drug interactions to be aware of:

• Drugs affecting P-glycoprotein or CYP3A4 enzymes
• Anticoagulants (warfarin, heparin) increase bleeding risk
• Substances to avoid: grapefruit and grapefruit juice

Always inform your healthcare provider about all medications and supplements.

Missed Dose

If you miss a dose of nintedanib:

• Skip the missed dose
• Take next dose at regular time
• Never take two doses together
• Consult doctor if multiple doses are missed

Overdose

Overdose symptoms may include:

• Severe gastrointestinal issues
• Liver dysfunction
• Increased bleeding risk

In case of suspected overdose:

• Seek emergency medical attention
• Treatment is supportive and symptomatic
• Store medication properly to prevent misuse

Storage

Proper storage instructions for nintedanib:

• Store at room temperature (20°C to 25°C / 68°F to 77°F)
• Keep in a dry place away from heat and moisture
• Maintain in original container until use
• Dispose of expired medication properly
• Keep out of reach of children and pets

Disclaimer

This information provides general knowledge about medications and does not cover all possible directions, drug interactions, or precautions. The content should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider for specific medical advice. While we strive for accuracy, we cannot guarantee the completeness or reliability of this information. We are not liable for any consequences resulting from the use of this information or from self-treatment practices.