Common use

Nexletol (bempedoic acid) is prescribed to help reduce “bad” LDL cholesterol in patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. It works by inhibiting ATP citrate lyase, an enzyme involved in cholesterol synthesis in the liver, lowering LDL levels and supporting heart health.

Dosage and direction

Take Nexletol orally once daily, with or without food. Swallow tablets whole with water. Dosage may be adjusted based on kidney function, other medications, or response to therapy. Continue regular cholesterol monitoring while on the medication.

Precautions

Inform your doctor if you have liver disease, kidney problems, gout, or a history of tendon disorders. Report any unexplained muscle pain, weakness, or yellowing of the skin or eyes. Maintain a healthy diet and follow recommended exercise and lifestyle measures for cardiovascular health. Consider these points:

• Liver disease or elevated liver enzymes
• Kidney impairment
• History of gout or tendon disorders
• Muscle pain, weakness, or signs of liver issues

Contraindications

Do not use Nexletol if you are allergic to bempedoic acid or any tablet components. Use cautiously in patients with severe liver disease or elevated liver enzymes.

Possible side effects

Common side effects include muscle aches, back pain, abdominal pain, constipation, or elevated uric acid. Serious side effects may include tendon rupture, liver problems, gout attacks, or severe allergic reactions. Seek immediate medical attention for serious symptoms.

• Muscle pain or weakness
• Back pain
• Abdominal pain
• Constipation
• Elevated uric acid levels
• Tendon rupture
• Liver problems
• Gout attacks
• Severe allergic reactions

Drug interactions

Nexletol may interact with statins, cholesterol‑lowering supplements, or medications that affect liver enzymes. Inform your doctor about all prescription medications, over‑the‑counter drugs, and supplements you are taking.

Missed dose

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Do not take two doses at once.

Overdose

Overdose may cause nausea, vomiting, muscle pain, or liver abnormalities. Seek immediate medical attention if an overdose is suspected.

Storage

Store Nexletol at room temperature, away from heat, moisture, and light. Keep tablets in their original container and out of reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug interactions, or precautions. This information cannot be used for self‑treatment or self‑diagnosis. Any specific instructions for a particular patient should be agreed with your health‑care adviser or doctor. We disclaim reliability of this information and any errors it may contain. We are not responsible for any direct, indirect, special, or other indirect damage resulting from the use of this information. Always consult a qualified health professional before starting or changing any medication.