Common Use

Motegrity is a prescription medication used to treat chronic idiopathic constipation (CIC) in adults. The active ingredient, prucalopride, is a selective serotonin‑4 (5‑HT₄) receptor agonist that enhances colonic motility and promotes regular bowel movements.

Dosage and Direction

Take Motegrity once daily at the same time, with or without food. Swallow the tablet whole with water and follow your doctor's dosing instructions exactly.

Precautions

Tell your doctor if you have a history of intestinal obstruction, severe liver disease, or mood disorders. Caution is advised for patients experiencing depression or suicidal thoughts, as rare psychiatric side effects have been reported.

Contraindications

• Do not use Motegrity if you are allergic to prucalopride.
• Avoid use in patients with known gastrointestinal perforation or obstruction.
• Do not prescribe for severe inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.

Possible Side Effects

Common side effects include headache, nausea, abdominal pain, and diarrhea. Rare but serious side effects may involve mood changes, palpitations, or allergic reactions.

Drug Interactions

Prucalopride has a low potential for drug interactions, but inform your doctor about all medications you are taking, especially those that affect the central nervous system or kidney function.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one - never double the dose.

Overdose

Symptoms of overdose may include severe diarrhea, headache, or abdominal cramps. Seek immediate medical attention if an overdose is suspected.

Storage

Store Motegrity at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of reach of children.

Disclaimer

We provide only general information about medications, which does not cover all directions, possible drug interactions, or precautions. This information cannot be used for self‑treatment or self‑diagnosis. Any specific instructions for a particular patient should be agreed upon with your health‑care adviser or the doctor in charge of the case. We disclaim reliability of this information and assume no responsibility for any direct, indirect, special, or other indirect damage resulting from its use.