Common Use

Mirtazapine is an antidepressant primarily used to treat major depressive disorder (MDD). It works by increasing the levels of neurotransmitters such as serotonin and norepinephrine in the brain, which help improve mood and emotional balance.

• Used in some cases for anxiety disorders, insomnia, or as an appetite stimulant
• Particularly beneficial for elderly patients
• Sedative properties help with depression accompanied by sleep disturbances

Dosage and Direction

• Typically taken once daily at bedtime (due to sedative effect)
• Standard starting dose: 15 mg
• Dosage may be gradually increased based on response and tolerance
• Can be taken with or without food

Important: Do not stop taking the medication abruptly without consulting your healthcare provider, as withdrawal symptoms may occur.

Precautions

Before taking mirtazapine, inform your doctor if you have:

• History of bipolar disorder
• Seizures
• Liver or kidney problems
• Suicidal thoughts

The drug can cause drowsiness, so avoid driving or operating machinery until you know how it affects you. Alcohol should be avoided as it can intensify drowsiness and dizziness.

Note: Elderly patients may be more sensitive to side effects such as confusion or low sodium levels.

Contraindications

• Should not be used by individuals allergic to the drug or its components
• Contraindicated with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs
• Use with caution during pregnancy and breastfeeding
• Not recommended for children or adolescents without medical supervision

Possible Side Effects

Common side effects include:

• Drowsiness
• Increased appetite
• Weight gain
• Dry mouth
• Dizziness
• Constipation

Rare but serious side effects:

• Low white blood cell counts
• Serotonin syndrome
• Suicidal thoughts (especially in younger adults)

Contact your doctor if you experience mood changes, fever, sore throat, or unusual bleeding.

Drug Interactions

Mirtazapine may interact with:

• Other antidepressants
• Antipsychotics
• Anticonvulsants
• Drugs affecting serotonin levels
• Alcohol (increases sedative effects)
• Benzodiazepines

Avoid St. John's Wort and other herbal supplements without doctor approval.

Always inform your healthcare provider about all medications and supplements you're taking.

Missed Dose

• Take as soon as you remember, unless close to next scheduled dose
• Do not double the dose
• Maintain consistent dosing times

If multiple doses are missed, consult your doctor for guidance.

Overdose

Symptoms may include:

• Confusion
• Rapid heartbeat
• Severe drowsiness
• Loss of consciousness
• Seizures (in severe cases)
• Cardiac issues

Seek emergency medical help if overdose is suspected.

Storage

• Store at room temperature (20°C-25°C or 68°F-77°F)
• Keep in dry place away from heat, light, and moisture
• Do not store in bathroom
• Keep out of reach of children and pets
• Properly discard expired medication

Disclaimer

The information provided is for general educational purposes only and does not constitute medical advice. This content does not cover all possible uses, directions, precautions, drug interactions, or adverse effects.

Important notes:

• Not intended for self-treatment or self-diagnosis
• Always consult your healthcare provider for personalized medical advice
• We cannot guarantee the accuracy or completeness of this information
• We are not liable for any consequences resulting from self-treatment or use of this information