Common Use

Micronase contains glyburide, a medication that helps lower blood glucose levels. It is part of the sulfonylureas class of diabetic drugs. Insulin, produced in the pancreas, reduces glucose synthesis in the liver and stimulates cells to absorb glucose from the bloodstream. Type 2 diabetes occurs when the body either does not produce enough insulin or fails to use it effectively. This leads to increased glucose production by the liver and insufficient insulin production, causing cells to become resistant. Micronase works by stimulating the pancreas to produce more insulin.

Dosage and Direction

The initial dose of Micronase is typically 2.5-5 mg daily, with a maximum dose of 1.25-20 mg per day. It is recommended to take Micronase with the first main meal of the day.

Precautions

• Inform your doctor if you have a heart condition, as Micronase and similar drugs may increase the risk of heart problems compared to diet treatment alone or diet plus insulin.
• Regularly test blood and urine for abnormal sugar levels while taking Micronase.
• Follow your doctor's diet and treatment recommendations.
• Micronase and other antidiabetic drugs may become less effective over time due to reduced responsiveness or worsening diabetes.
• Notify your doctor if you are pregnant or breastfeeding.

Contraindications

Micronase should not be used in patients with allergies to similar medications such as chlorpropamide or glipizide, or those suffering from diabetic ketoacidosis. Symptoms of diabetic ketoacidosis include nausea, fatigue, excessive thirst, pain below the breastbone, and fruity breath.

Possible Side Effects

• Common side effects: Nausea, bloating, heartburn, rashes, low blood sugar, blurred vision, and weight gain.
• Serious but rare side effects: Hepatitis, jaundice, and hyponatremia.
• Hypoglycemia is more likely in elderly, weak, or undernourished individuals, especially those with liver, adrenal, kidney, or pituitary gland issues.
• Avoid alcohol, skipping meals, or taking unprescribed medications to reduce the risk of hypoglycemia.
• Factors such as fever, infection, surgery, trauma, or excessive exercise may also increase risks.

Drug Interactions

• Do not combine Micronase with Bosentan (Tracleer) due to increased liver toxicity and reduced effectiveness of both drugs.
• Thiazide diuretics like hydrochlorothiazide (Hydrodiuril) may increase blood glucose levels and reduce Micronase's effects.
• Inform your doctor about all medications you are taking, including over-the-counter drugs, antibiotics, antidiabetic agents, airway-opening drugs, anabolic steroids, antacids, aspirin, beta blockers, blood thinners, calcium channel blockers, and others.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose. Resume your regular dosing schedule the next day.

Overdose

Overdose symptoms of Micronase include pale skin, seizures, coma, shallow breathing, and low blood sugar. Seek immediate medical help if you experience these symptoms.

Storage

Store Micronase at room temperature (59-77°F or 15-25°C), away from light, moisture, children, and pets. Do not use after the expiration date.

Disclaimer

This information provides general details about Micronase and does not cover all directions, drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions. We disclaim responsibility for any errors in this information or for any direct, indirect, or special damages resulting from its use or self-treatment.