Common Use

Letairis (ambrisentan) is prescribed for adults with pulmonary arterial hypertension (PAH) to improve exercise ability and slow disease progression. It works as an endothelin receptor antagonist, blocking the action of endothelin‑1, a substance that causes blood vessels in the lungs to narrow.

Dosage and Direction

Letairis is usually taken orally once daily, with or without food. Swallow tablets whole with water. Dosage is individualized based on liver function and other health conditions. Regular monitoring of liver function and hemoglobin levels is recommended.

Precautions

Inform your doctor if you have liver disease, heart problems, low blood pressure, or a history of anemia. Avoid pregnancy while taking Letairis, as it may cause birth defects. Monitor for signs of swelling, dizziness, or jaundice.

Contraindications

Do not use Letairis if allergic to ambrisentan or any component of the tablet. It is contraindicated in pregnancy and in patients with severe liver impairment.

Possible Side Effects

• Swelling in the legs or ankles
• Nasal congestion
• Flushing
• Headache
• Fatigue
• Liver toxicity
• Low red blood cell count (anemia)
• Severe allergic reactions

Drug Interactions

Letairis may interact with cyclosporine, rifampin, or other medications that affect liver enzymes. Inform your doctor of all prescription drugs, over‑the‑counter products, and supplements you are taking.

Missed Dose

If a dose is missed, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

Overdose

Overdose may cause severe hypotension, dizziness, or liver dysfunction. Seek immediate medical attention if overdose is suspected.

Storage

Store Letairis at room temperature, away from heat, moisture, and light. Keep tablets in the original container and out of reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on this site cannot be used for self‑treatment or self‑diagnosis. Any specific instructions for a particular patient should be agreed with your health‑care adviser or doctor in charge of the case. We disclaim reliability of this information and any errors it may contain. We are not responsible for any direct, indirect, special, or other indirect damage resulting from the use of the information on this site or from self‑treatment.