Common Use

Hydroxyurea is used to treat certain types of cancer, including melanoma, chronic myelocytic leukemia, ovarian cancer, and primary skin cancer of the head and neck. It is also used to manage sickled red blood cells. The active ingredient in this drug is hydroxyurea. While its exact mechanism of action is not fully understood, it is believed to be cell cycle-specific, targeting the S phase of cell division. It interferes with DNA synthesis but does not affect RNA or protein synthesis.

Dosage and Direction

Take Hydroxyurea exactly as prescribed by your doctor. Follow these guidelines for proper use:

• Drink plenty of water to help your kidneys process the drug and reduce side effects.
• You may take it with or without food.
• If instructed, empty the capsule contents into a glass of water, mix thoroughly, and drink immediately.
• Avoid touching or inhaling the powder inside the capsule.
• Do not stop taking the medication even if nausea or vomiting occurs.
• Contact your doctor if you vomit immediately after taking a dose.

This medication may lower the number of immune cells, increasing infection risk.

Precautions

Before taking Hydroxyurea, discuss your medical history with your doctor, especially if you:

• Are undergoing radiation therapy.
• Are taking interferon medications (e.g., Actimmune, Betaseron, Roferon, Intron, Infergen, Alferon, Rebetron, Rebif).
• Have bone marrow disorders, liver disease, or kidney disease.

Contraindications

Do not use Hydroxyurea if:

• You are allergic to any of its ingredients.
• You have bone marrow depression (leukopenia or thrombocytopenia).
• You are pregnant or breastfeeding, as it may harm the baby.

Possible Side Effects

Hydroxyurea may cause the following side effects:

• Allergic reactions (facial swelling, rash, hives, red spots).
• Skin ulcers, redness, or darkening.
• Fever, flu-like symptoms, chills.
• Mouth sores or white patches.
• Body aches, nausea, vomiting, loss of appetite, diarrhea.
• Easy bruising, bleeding, or unusual weakness.

Drug Interactions

Avoid starting or stopping any medication without consulting your doctor. Inform your healthcare provider about all drugs and supplements you're taking, especially:

• Anti-cancer medications.
• Didanosine or stavudine.
• Gout treatments.

Missed Dose

If you miss a dose:

• Skip the missed dose if it's almost time for the next one.
• Do not take a double dose.

Overdose

Seek immediate medical help if an overdose occurs. Symptoms may include:

• Severe skin reactions (violet erythema, scaling of hands and feet).
• Soreness, generalized hyperpigmentation.
• Edema on palms and soles.
• Stomatitis (mouth inflammation).

Storage

Store Hydroxyurea at room temperature (20-25°C or 68-77°F), away from moisture and heat.

Disclaimer

This information is for general knowledge only and does not replace professional medical advice. Always consult your healthcare provider before starting or stopping any treatment. We are not liable for any inaccuracies or consequences of self-treatment.