Common Use

Gemfibrozil is a fibric acid derivative, similar to fenofibrate (Tricor). It works by reducing triglycerides and increasing high-density lipoprotein (HDL) cholesterol, lowering the risk of atherosclerosis, stroke, and heart attack. The exact mechanism of action is unknown. Gemfibrozil is particularly effective in treating high cholesterol and triglyceride levels in patients with pancreatitis.

Dosage and Direction

The recommended dose is 600 mg taken twice daily, 30 minutes before breakfast and dinner.

Precautions

• Follow your doctor's instructions on diet, exercise, and weight control, as this medication is part of a broader treatment plan.
• Avoid cholesterol-rich or high-fat foods.
• Regular blood fat monitoring is required.
• Your doctor may check kidney or liver function periodically.
• Inform your doctor if you have liver disease, gallbladder disease, or severe kidney disease.

Contraindications

• Allergic reactions to gemfibrozil
• Liver disease
• Gallbladder disease
• Severe kidney disease
• Co-administration with repaglinide (Prandin)

Possible Side Effects

• Severe upper stomach pain after taking gemfibrozil or eating
• Jaundice
• Blurred vision or eye pain
• Seeing halos around lights
• Painful urination

Drug Interactions

• Increased risk of rhabdomyolysis (muscle injury) when used with statins like pravastatin (Pravachol), lovastatin (Mevacor), rosuvastatin (Crestor), simvastatin (Zocor), fluvastatin (Lescol), or atorvastatin (Lipitor).
• Concomitant use with warfarin increases bleeding risk, dose adjustment may be needed.
• Gemfibrozil raises blood levels of repaglinide (Prandin) in diabetic patients.
• Cholestyramine (Questran) and colestipol (Colestid) reduce gemfibrozil's effectiveness. Take gemfibrozil 1 hour before or 4-6 hours after these medications.

Missed Dose

Take the missed dose as soon as you remember. If it's almost time for the next dose, skip it. Do not double the dose. Resume the regular schedule the next day.

Overdose

Symptoms include nausea, vomiting, diarrhea, stomach cramps, and muscle or joint pain. Seek emergency medical help if overdose is suspected.

Storage

Store at room temperature (20-25°C or 68-77°F).

Disclaimer

This information does not cover all possible uses, interactions, or side effects. It is not for self-diagnosis or self-treatment. Always consult your healthcare provider. We disclaim liability for any errors or consequences from relying on this content.