Common Use

Estradiol belongs to the class of medications called estrogen replacement therapy. Estrogen is a hormone produced by the ovaries. Specific estrogen receptors are located in various organs, including the uterus, vagina, urethra, mammary glands, liver, hypothalamus, and pituitary.

Estrogen plays a key role in:

• Development and growth of female reproductive organs during puberty
• Formation of female secondary sexual characteristics
• Regulating the menstrual cycle and endometrial changes
• Bone health and prevention of bone resorption
• Suppression of lactation in high concentrations

Estradiol is primarily used to treat menopause symptoms such as hot flashes, vaginal dryness, burning, and irritation. It is also prescribed for certain cancer treatments in both women and men, as well as for osteoporosis management.

Dosage and Direction

Always follow your doctor's prescription and recommendations precisely.

• Tablets: Typically taken once daily
• Cyclic regimen for women: 23 days of medication followed by 5 days without treatment
• Patches: Apply to clean, hairless skin on the hip or shoulder (never on breasts)

Precautions

Before taking Estradiol, inform your doctor if you have:

• Severe blood disorders or circulation problems
• History of hormone-related cancers (breast or uterine cancer)
• Unexplained vaginal bleeding

Long-term Estradiol use may increase risks of:

• Breast cancer
• Heart attack
• Stroke

Estradiol is contraindicated during pregnancy.

Contraindications

Do not use Estradiol if you have:

• Hypersensitivity to estrogens
• Active pregnancy
• Estrogen-dependent cancers
• Unexplained genital or uterine bleeding
• Active thrombophlebitis or thromboembolic disorders

Use with caution in patients with:

• History of blood clotting disorders
• Liver diseases or jaundice
• Gallbladder disease
• Endometriosis
• Severe hypercalcemia

Possible Side Effects

Common side effects:

• Breast tenderness or pain
• Headaches
• Hair loss
• Spotting or breakthrough bleeding
• Mild nausea or vomiting
• Stomach discomfort or bloating

Serious side effects requiring immediate medical attention:

• Allergic reactions (rash, swelling, breathing difficulties)
• Chest pain or shortness of breath
• Leg pain or swelling (possible blood clot)
• Severe headaches or vision changes
• Jaundice or dark urine
• Unusual vaginal bleeding or discharge
• Neurological symptoms (slurred speech, weakness)

Drug Interactions

Estradiol may interact with:

• Cyclosporine: Increased risk of kidney or liver damage
• Dantrolene: Increased risk of liver disease
• Warfarin: Altered blood clotting effects
• Anticonvulsants (carbamazepine, phenytoin): May reduce Estradiol effectiveness
• Rifampin and barbiturates: May increase Estradiol metabolism

Missed Dose

If you miss a dose:

• Take it as soon as you remember, unless it's nearly time for the next dose
• Never double dose to make up for a missed one
• Skip the missed dose if your next scheduled dose is soon

Overdose

Seek immediate medical help if overdose is suspected. Symptoms may include:

• Severe nausea or vomiting
• Unusual vaginal bleeding

Storage

Proper storage guidelines:

• Keep in a dry, tight container
• Store at room temperature (15-30°C or 59-86°F)
• Protect from direct sunlight
• Keep out of reach of children and pets

Disclaimer

This information provides general guidelines about Estradiol and does not replace professional medical advice. Always consult your healthcare provider for personalized guidance. The content may not cover all possible uses, precautions, or interactions. We are not liable for any consequences resulting from self-treatment based on this information.