Common Use

Eldepryl is a monoamine oxidase inhibitor (MAOI) prescribed to manage symptoms of Parkinson's disease, a brain disorder affecting movement. Parkinson's disease reduces dopamine-producing nerve cells in the brain, leading to movement-related difficulties. Eldepryl helps maintain dopamine levels for longer periods, aiding in smoother movement. It does not have standalone anti-Parkinson effects and must always be used alongside levodopa/carbidopa.

Dosage and Direction

Take Eldepryl orally daily after breakfast and lunch. Avoid eating or drinking for at least 5 minutes after taking the orally disintegrating tablet. The recommended adult dose is 10 mg per day, split into two 5 mg doses.

Note: This information is for reference only. Always consult your doctor before starting any medication to ensure optimal results.

Precautions

Avoid foods high in tyramine, such as:

• Pickled herring, air-dried meats, aged or fermented meats, poultry, sausage, salami, and improperly stored beef, fish, or liver.
• Aged cheeses like blue, brie, cheddar, parmesan, and swiss.
• Tap beer or unpasteurized beer.
• Sauerkraut, soybeans, soy sauce, tofu, miso soup, bean curd, fava beans, and yeast extracts.

Tyramine can dangerously increase blood pressure when combined with Eldepryl. Use with caution if you have peptic or duodenal ulcers, labile hypertension, cardiac arrhythmias, severe angina pectoris, severe liver or kidney dysfunction, or psychosis. Higher doses (over 30 mg daily) may reduce MAO-A inhibition, increasing side effects. Be cautious of lightheadedness or dizziness when standing up. Eldepryl is not recommended during pregnancy, lactation, or breastfeeding without medical advice.

Contraindications

Do not use Eldepryl if you are hypersensitive to selegiline or any of its components. Avoid using Demedrol or similar narcotics while on Eldepryl. Also, avoid Eldepryl if you have taken meperidine, propoxyphene, tramadol, methadone, cough or cold medicines with dextromethorphan, or other MAO inhibitors like isocarboxazid, tranylcypromine, phenelzine, rasagiline, or transdermal selegiline within the past 14 days.

Possible Side Effects

• Allergic reactions, confusion, sudden severe headache, blurred vision, nausea, speech or balance problems, vomiting, seizures, chest pain, or sudden numbness or weakness.
• Lightheadedness, fainting, hallucinations, restlessness, agitation, irritability, twitching muscles, or painful urination.
• Less severe symptoms: dizziness, weakness, insomnia, runny or stuffy nose, back pain, or constipation.

Stop using Eldepryl and consult your doctor immediately if you experience any of these side effects or any unusual symptoms.

Drug Interactions

Eldepryl may interact with:

• Diet pills, cold medicines containing ephedrine, pseudoephedrine, or phenylephrine.
• Carbamazepine, nafcillin, rifampin.
• Antidepressants like amitriptyline, fluoxetine, sertraline, or venlafaxine.
• Phenobarbital.

Drug interactions do not always require stopping a medication but may alter its effects. Discuss with your doctor how to manage these interactions.

Missed Dose

If you miss a dose, take it as soon as you remember. Do not take it if it's almost time for your next dose. Avoid doubling doses. Continue with your regular schedule the next day.

Overdose

Symptoms of overdose include severe headache, vision problems, sweating, hallucinations, lightheadedness, cool or clammy skin, fast or irregular heartbeat, fainting, or seizures. Seek immediate medical attention if these occur.

Storage

Store Eldepryl at room temperature between 20-25°C (68-77°F).

Disclaimer

This information is intended for general awareness and does not cover all uses, interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider for personalized guidance. We are not responsible for any consequences resulting from the use or misuse of this information.