Common Use

Dapsone is an anti-infective medication used to treat several conditions. It is commonly combined with rifampicin and clofazimine to manage dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease), which is caused by Mycobacterium leprae. Additionally, it is used to treat pneumonia caused by Pneumocystis jiroveci. When combined with pyrimethamine, Dapsone is also effective in treating malaria.

Dosage and Direction

Take Dapsone with a full glass of water. To minimize stomach upset, it can be taken with food. Consistent daily timing is recommended for maximum effectiveness. Dosage varies based on the condition:

• Leprosy (adults): 50-100 mg orally once daily for 2-5 years.
• Dermatitis herpetiformis: 50 mg orally once daily, potentially increasing to 300 mg daily.
• Pneumocystis pneumonia (adults): 100 mg orally once daily for 2-3 weeks.

Follow your doctor's instructions carefully and avoid exceeding the recommended dosage.

Precautions

Dapsone may cause rare but serious liver or blood issues, indicated by symptoms such as bruising, pinpoint red spots, sore throat, fever, pale skin, jaundice, or rash. Seek immediate medical attention if these occur. Serious skin reactions, though rare, can also occur. Inform your doctor if you have methemoglobin reductase deficiency, G6PD deficiency, or liver disease. Avoid direct sunlight as Dapsone may increase skin sensitivity.

Contraindications

Do not use Dapsone if you have a known hypersensitivity to the medication.

Possible Side Effects

Contact your doctor immediately if you experience signs of an allergic reaction, such as hives, rash, facial swelling, or difficulty breathing. Other serious symptoms to report include:

• Pale skin, bruising, or pinpoint red spots
• Sore throat, fever, or jaundice
• Muscle weakness, numbness, tingling, or bluish skin
• Abdominal pain, difficulty breathing, or unusual tiredness
• Dark urine or pale stools

Drug Interaction

Rifampin can reduce blood levels of Dapsone. Folic acid antagonists, such as pyrimethamine, may increase the risk of hematologic reactions.

Missed Dose

If you miss a dose, skip it and continue with the next scheduled dose. Do not double the dosage.

Overdose

Seek emergency medical help if you experience symptoms such as excitation, seizures, nausea, vomiting, or bluish skin color.

Storage

Store Dapsone tablets at room temperature (15-30°C or 59-86°F) in a dry, tight container away from moisture and sunlight.

Disclaimer

The information provided is general and does not cover all possible directions, drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions. We disclaim any responsibility for the reliability of this information or any consequences resulting from its use.