Common use

Contrave is a combination medication primarily used as part of a weight management plan in adults with obesity or overweight conditions, especially those with weight-related health issues like hypertension or type 2 diabetes.

• Bupropion is an atypical antidepressant that affects dopamine and norepinephrine levels.
• Naltrexone is an opioid antagonist that affects brain pathways involved in cravings and reward.

Together, they help reduce appetite and control food cravings. This combination is typically used alongside a reduced-calorie diet and increased physical activity.

Dosage and direction

The medication is taken orally, usually starting with a low dose that is gradually increased over several weeks to minimize side effects.

• Take the tablets twice daily, with or without food.
• Avoid high-fat meals due to increased risk of seizures.
• Follow the titration schedule provided by your healthcare provider.
• Do not crush, chew, or split the tablets.

Precautions

Before using this medication, inform your doctor if you have:

• A history of seizures or eating disorders
• Uncontrolled hypertension
• Opioid dependence

Regular monitoring of blood pressure and mental health is advised, as bupropion may increase the risk of suicidal thoughts in some individuals. Naltrexone can block the effects of opioid pain medications, so it must not be used by patients currently taking opioids. Avoid alcohol and high-fat meals during treatment.

Contraindications

Contrave is contraindicated in individuals with:

• Uncontrolled hypertension or seizure disorders
• Bulimia or anorexia nervosa
• Undergoing abrupt withdrawal from alcohol, benzodiazepines, or barbiturates
• Currently using opioids or undergoing opioid withdrawal
• Known hypersensitivity to either component

Use during pregnancy is not recommended unless clearly needed.

Possible side effects

Common side effects include:

• Nausea, constipation, headache
• Dizziness, dry mouth, insomnia
• Increased blood pressure or heart rate

Rare but serious side effects include seizures, suicidal thoughts, liver damage, or severe allergic reactions. Report any unusual or severe symptoms to a healthcare provider immediately.

Drug interactions

This medication may interact with:

• MAO inhibitors, opioids, antidepressants
• Certain antipsychotics
• Drugs that lower the seizure threshold
• Substances affecting the central nervous system

Alcohol may enhance the risk of side effects and should be avoided. Always inform your doctor about all medications and supplements you are taking.

Missed dose

If you miss a dose:

• Take it as soon as you remember, unless it is close to the next dose.
• Do not take two doses at once.

Missing doses may reduce treatment effectiveness. Take the medication at the same times each day for consistency.

Overdose

Overdose symptoms may include:

• Seizures, hallucinations
• Rapid heartbeat, confusion
• Loss of consciousness

Seek emergency medical help if overdose is suspected. Supportive care is provided as there is no specific antidote. Do not exceed the prescribed dose.

Storage

• Store at room temperature away from heat, moisture, and direct light.
• Keep in the original container, out of reach of children and pets.
• Do not use after the expiration date.
• Dispose of unused or expired medicine according to local regulations.

Disclaimer

We provide general information about medications which does not cover all directions, possible drug interactions, or precautions. The information on this site cannot be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions related to your condition. We disclaim responsibility for any inaccuracies in this information or consequences of its use, including self-treatment.