Common Use

Combimist L Inhaler contains the following active ingredients: Levosalbutamol (50 mg) and Ipratropium bromide (20 mg). Please note that this medication may be available in different strengths for each active ingredient. Combimist L Inhaler works by relaxing the airways and muscles, helping to open the air passages in the lungs.

Levosalbutamol is a short-acting β2-adrenergic receptor agonist, approved for asthma, and belongs to the bronchodilator family. It relaxes the muscles of the airways, allowing air to flow smoothly through the lungs.

Ipratropium bromide is also a bronchodilator and works similarly. However, it is not intended to treat bronchospasm attacks as a quick-fix solution.

Dosage and Direction

Combimist L Inhaler is available as a nasal spray but must be inhaled through the mouth. The recommended dosage is up to 3 times daily, with a maximum of 42 mcg per nostril (approximately two sprays).

Precautions

Consult your doctor before using Combimist L Inhaler, especially if you have allergies, other prescriptions, existing medical conditions, or are pregnant. Inform your doctor if you are allergic to ipratropium or levosalbutamol. Follow your doctor's prescription and read the information on the packaging carefully. Contact your doctor or pharmacist immediately if you experience any allergic reactions, such as:

• Rash, hives, or itching
• Shortness of breath or wheezing
• Cough or swelling of the face, lips, tongue, or throat

Animal studies have not shown risks during pregnancy, but the safety of using Combimist L Inhaler during pregnancy is not fully established.

Contraindications

Ipratropium bromide should not be used by patients with hypersensitivity to atropine or its derivatives. Its use for treating bronchospasm in acute COPD exacerbation is not well-studied, and alternative drugs may be preferred. Combining Ipratropium bromide with beta agonists is not proven to be more effective than using it alone for acute COPD exacerbation. Rare hypersensitivity reactions, such as urticaria, angioedema, rash, oropharyngeal edema, and bronchospasm, have been reported.

Possible Side Effects

Levosalbutamol is generally well-tolerated, but common side effects may include:

• Increased heart rate
• Muscle pain
• Gastric dysfunction

Other potential side effects of Combimist L Inhaler include:

• Severe hypokalemia
• Tremors, especially in the hands
• Vomiting or nausea
• Diarrhea
• Fatigue
• Dizziness
• Muscle cramps

Contact your doctor if you experience any side effects, especially if they worsen. Report any new side effects to your local FDA administration.

Drug Interaction

Ipratropium bromide is safe and effective when used with beta-adrenergic bronchodilators. It can also be used with other pulmonary medications, such as methylxanthines and corticosteroids, without adverse interactions.

Missed Dose

Take the missed dose as soon as you remember. If it is close to the next dose, skip the missed one and continue with the regular schedule. Do not take two doses at the same time or exceed the prescribed amount. Consult your doctor if unsure.

Overdose

If you suspect an overdose, contact your local poison control center or hospital immediately. Symptoms of overdose may include:

• Wheezing or chest tightness
• Fever or itching
• Severe cough or blue/gray skin discoloration
• Seizures or swelling of the face, lips, tongue, or throat
• Trouble breathing or sudden vision changes
• Rash

Storage

Store Combimist L Inhaler in a dry place at temperatures below 25°C (77°F). It can be used at temperatures between 15°C and 30°C (59°F to 86°F) for short periods. Keep it away from extreme heat and moisture, and out of reach of children and pets.

Disclaimer

This information is provided for general purposes and does not cover all directions, drug interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider for specific instructions. We are not responsible for any errors in the information or any consequences of self-treatment.