Common Use

Clomipramine is a tricyclic antidepressant primarily used to treat obsessive-compulsive disorder (OCD). It is also prescribed for depression, panic disorder, chronic pain, and occasionally for cataplexy in narcolepsy. The medication works by increasing serotonin and norepinephrine levels in the brain, which helps improve mood and reduce obsessive thoughts.

Dosage and Direction

Clomipramine is taken orally, usually 1 to 3 times daily, with or without food. Treatment typically starts at a low dose and is gradually increased to minimize side effects. Do not stop taking it suddenly without consulting your doctor, as withdrawal symptoms may occur.

Precautions

Inform your doctor if you have a history of heart disease, seizures, urinary retention, glaucoma, or bipolar disorder. Avoid alcohol and activities requiring alertness until you know how the medication affects you. Elderly patients may be more sensitive to side effects such as dizziness or confusion.

Contraindications

Do not use clomipramine if you are allergic to it or other tricyclic antidepressants. It is contraindicated in patients currently taking or who have recently taken MAO inhibitors. It should also be avoided in individuals with recent heart attacks or severe heart rhythm disorders.

Possible Side Effects

Common side effects include dry mouth, drowsiness, dizziness, constipation, and weight gain. Serious side effects may include seizures, irregular heartbeat, serotonin syndrome, or suicidal thoughts in young people. Seek immediate medical attention if you experience chest pain, severe agitation, or fainting.

Drug Interaction

Clomipramine may interact with SSRIs, MAO inhibitors, anticholinergics, CNS depressants, and drugs that affect heart rhythm, such as quinidine and antiarrhythmics. Combining it with serotonergic drugs increases the risk of serotonin syndrome. Always inform your doctor about all medications and supplements you are taking.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed one. Do not double the dose to catch up.

Overdose

Overdose symptoms may include extreme drowsiness, confusion, rapid heartbeat, seizures, or coma. Clomipramine overdose can be life-threatening. Seek emergency medical help immediately if an overdose is suspected.

Storage

Store clomipramine at room temperature, away from heat, moisture, and direct light. Keep it in a tightly closed container and out of reach of children. Do not use it after the expiration date.

Disclaimer

We provide only general information about medications, which does not cover all directions, possible drug interactions, or precautions. The information on this site cannot be used for self-treatment or self-diagnosis. Any specific instructions for a particular patient should be agreed upon with your healthcare provider or doctor in charge of the case. We disclaim the reliability of this information and any errors it may contain. We are not responsible for any direct, indirect, special, or other damages resulting from the use of the information on this site or the consequences of self-treatment.