Common Use

Cialis is a highly effective and selective inhibitor of phosphodiesterase type 5 (PDE5), specifically targeting cyclic guanosine monophosphate (cGMP). During sexual stimulation, the release of nitric oxide triggers the inhibition of PDE5 by Cialis, leading to increased cGMP levels in the penile cavernous body. This process results in the relaxation of arterial smooth muscles and enhanced blood flow to the penile tissues, facilitating erections. Cialis only works in the presence of sexual stimulation and has no effect otherwise. It helps improve erections and supports successful sexual intercourse. The drug remains active for up to 36 hours, with effects noticeable as early as 16 minutes after ingestion when sexual arousal is present.

Dosage and Direction

The recommended dosage of Cialis is 20 mg, to be taken at least 16 minutes before sexual activity. Its effects can last for up to 36 hours. Cialis should be taken once daily, and the recommended dose should not be exceeded.

Precautions

Avoid consuming Cialis with grapefruit juice, alcoholic beverages, or tobacco. Combining Cialis with tobacco may increase the risk of NAION (sudden vision loss due to optic nerve damage). Inform your healthcare provider if you have:

• Abnormalities of the penis, such as curvature or congenital defects
• History of coronary artery disease, arrhythmia, angina, heart attack, or heart failure
• Hypotension or hypertension
• Bleeding disorders, stomach ulcers, diabetes, or hyperlipidemia
• Sickle-cell anemia or liver/kidney failure

Contraindications

Cialis is contraindicated in patients using organic nitrates, either regularly or intermittently, as it can intensify the hypotensive effects of nitrates.

Possible Side Effects

Common side effects of Cialis include facial flushing, headaches, stomach upset, diarrhea, flu-like symptoms, and nausea. Rare side effects may include:

• Low blood pressure
• Blurred vision or changes in color vision
• Abnormal ejaculation
• Prolonged erections (priapism) lasting more than 6 hours

Seek immediate medical attention if an erection lasts longer than 4 hours, as it may cause permanent damage. Patients with pre-existing heart conditions may experience worsening symptoms while using Cialis.

Drug Interactions

Co-administration of Cialis with organic nitrates can cause severe hypotension, which can be dangerous. Avoid using Cialis with medications such as:

• Erythrityl Tetranitrate, Isosorbide Dinitrate, Isosorbide Mononitrate
• Nitroglycerin, Pentaerythritol Tetranitrate

Medications like erythromycin, ketoconazole, itraconazole, indinavir, and ritonavir can increase Cialis levels and toxicity. Inform your doctor if you are taking:

• Atazanavir, Bunazosin, Clarithromycin, Doxazosin, Erythromycin
• Indinavir, Itraconazole, Ketoconazole, Moxisylyte, Nefazodone
• Nelfinavir, Phenoxybenzamine, Phentolamine, Prazosin, Saquinavir
• Telithromycin, Terazosin, Trimazosin, Urapidil

Your Cialis dosage may need adjustment if you are using these medications.

Missed Dose

There is no concern about missing a dose of Cialis if it is taken as needed for erectile dysfunction.

Overdose

An overdose of Cialis may result in side effects described earlier. Seek immediate medical attention if you suspect an overdose.

Storage

Store Cialis at room temperature in a tightly sealed container, away from moisture, sunlight, children, and pets.

Disclaimer

This information provides a general overview of medications and does not cover all possible directions, drug interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider or doctor for specific instructions tailored to your needs. We do not guarantee the accuracy or completeness of this information and are not liable for any direct, indirect, or consequential damages resulting from its use or the outcomes of self-treatment.