Varnitrip (Tripada Health Care)
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Packages: 0.5/1 mg Active component: VareniclineCategories list: Stop Smoking |
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Tablets, to be exact capsules of Champix (Chantix) are made by known German company Pfizer. They are intended for treatment of nicotinic dependence. The sense that during preparation reception bent for to smoking decreases, weakens physical pleasure from cigarets that allows to refuse at all gradually this habit, the cancellation syndrome is expressed more poorly, than simply at refusal of smoking. At this Champix (Chantix) doesn't contain some nicotine unlike many similar preparations.
How to accept Champix (Chantix) from smoking?
To give up smoking with Champix (Chantix), in the beginning it is necessary to appoint day of definitive refusal of smoking. Capsules should to start be accepted for one-two weeks about the established day under such scheme:
- 1-3 day — 0,5 mg once a day,
- 4-7 day — 0,5 mg twice a day,
- About 8 days till the end of treatment — 1 mg two times day.
Time of reception of a tablet has no special value: it is possible both during meal, and between food intakes. Simply swallow a capsule, having washed down with water.
If at transition to a dosage in 1 mg there are by-effects which are badly transferred, the dose should be reduced twice.
Course of treatment in practice very individual. Recommended — 12 weeks. But not all can say goodbye to smoking in this time. And consequences of longer reception weren't studied and weren't investigated. In general, it is good, if treatment to you is appointed by the doctor, and you can consult and modify with it a dosage and duration of a course.
Pharmacological action
Preparation for treatment of nicotinic dependence. Varenicline with high affinity and selectivity contacts α4β2-n-holinoretseptorami in which relation it is partial agonist nicotine, i.e. simultaneously shows agonist activity (but to a lesser degree, than nicotine) and antagonism in the presence of nicotine.
Electrophysiological researches in vitro and neurobiological researches in vivo have shown that Varenicline contacts α4β2-n-holinoretseptorami and stimulates them, but in much smaller degree, than nicotine. Nicotine competitive contacts the same site of a receptor to which Varenicline possesses higher affinity. Thus, Varenicline effectively blocks ability of nicotine to stimulate α4β2-receptors and to activate mesolimbic dopamine system - neuronal the mechanism which underlies realization of mechanisms of formation of nicotinic dependence (reception of pleasure from smoking).
Efficiency of Varenicline as means for treatment of nicotinic dependence is caused its partial agonist concerning α4β2-nicotinic receptors linkage with which reduces bent for to smoking and facilitates display of a syndrome of cancellation (agonist activity) and simultaneously leads to reduction of feeling of pleasure from smoking (antagonism in the presence of nicotine).
