Common Use

Asacol is an anti-inflammatory drug that targets the gut lining to reduce inflammation, tissue damage, and diarrhea. It is used to treat conditions such as ulcerative colitis, proctosigmoiditis, and proctitis. The medication becomes active in the small intestine before reaching the large intestine. It may also be effective in treating Crohn's disease, which affects the small bowel. Asacol contains the active ingredient mesalamine, which is released when the pH is greater than 7, and olsalazine, which is active in the distal segments of the gastrointestinal tract.

Dosage and Direction

Consult your doctor before starting treatment with Asacol. Take the medication orally with a meal or a glass of milk. Swallow the tablet whole with water; do not crush, break, or chew it. The recommended daily dose for moderately active ulcerative colitis is 4.8g divided into three doses for up to 6 weeks in adults. For mild acute exacerbations, a lower dose of 2.4g daily is suggested. For maintenance of remission in ulcerative colitis and Crohn's ileocolitis, take up to 2.4g daily in divided doses. Dosage adjustments are necessary for patients with renal impairment. This medication is not recommended for children.

Precautions

Asacol is not recommended for patients with renal impairment and should be used cautiously in those with elevated blood urea or proteinuria. Monitor renal function in patients taking Asacol, as mesalazine can cause nephrotoxicity. Avoid using Asacol during pregnancy, while trying to conceive, or while breastfeeding without medical advice. Consult your doctor if breastfeeding is necessary, as adverse effects on the infant are possible.

Contraindications

Asacol is contraindicated in individuals hypersensitive to its ingredients, salicylates, aminosalicylates, or those with renal sensitivity to sulfasalazine. It is also not recommended for patients with severe hepatic impairment, acute or chronic interstitial nephritis, gastric or duodenal ulcers, or a hemorrhagic tendency. The safety of Asacol during pregnancy and lactation is not established.

Possible Side Effects

Side effects may include allergic reactions, colic, fever, nasopharyngitis, headache, severe abdominal pain, cramping, dyspepsia, jaundice, and bloody diarrhea. Less serious side effects include mild nausea, vomiting, stomach cramps, diarrhea, constipation, hemorrhoids, gas, stool abnormalities, fever, sore throat, flu-like symptoms, dizziness, fatigue, and skin rash. Discontinue use and consult your doctor if you experience any unusual symptoms.

Drug Interaction

Avoid co-administering Asacol with medications that lower stool pH, such as lactulose, as they may inhibit the release of the active ingredient. Do not use Asacol or other salicylates for six weeks after receiving the chickenpox vaccine due to the risk of Reye's syndrome. Asacol may reduce the absorption of digoxin and increase levels of thiopurine medications. Monitor warfarin therapy if used with Asacol. Inform your doctor if you are taking medications such as azathioprine, mercaptopurine, or NSAIDs.

Missed Dose

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to make up for the missed one. Take your medication at the same time each day to avoid missing doses.

Overdose

Symptoms of an Asacol overdose include confusion, dehydration, diarrhea, dizziness, drowsiness, fever, headache, rapid breathing, ringing in the ears, sweating, and vomiting. Seek immediate medical attention if you experience any of these symptoms.

Storage

Store Asacol at room temperature between 20-25°C (68-77°F).

Disclaimer

The information provided is general and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Always consult your healthcare provider for specific instructions. We are not responsible for any direct, indirect, or consequential damages resulting from the use of this information or self-treatment.