Common Use

Alfacip, an analogue of vitamin D, contains the active ingredient alfacalcidol. It is used to treat conditions related to impaired calcium metabolism caused by 1-α hydroxylation disorders, particularly in cases of reduced renal function. Conditions treated by Alfacip include:

• Renal osteodystrophy
• Hyperparathyroidism (parathyroid hormone deficiency affecting calcium and phosphorus absorption)
• Hypoparathyroidism
• Neonatal hypocalcemia
• Nutritional and malabsorptive rickets and osteomalacia
• Pseudo-deficiency (vitamin D-dependent) rickets and osteomalacia
• Hypophosphatemic vitamin D-resistant rickets and osteomalacia
• Osteoporosis

Dosage and Direction

The standard daily dose of Alfacip is 1 mcg/day. Dosage adjustments may be necessary for:

• Elderly patients
• Neonates and premature infants
• Children weighing under 20 kg

Precautions

Patients taking Alfacip should undergo regular monitoring to prevent hypercalcemia, including:

• Plasma calcium levels
• Parathyroid hormone levels
• Alkaline phosphatase tests
• Radiographic and histological examinations

Patients with chronic renal failure require close monitoring, as prolonged hypercalcemia may worsen kidney function.

Contraindications

Alfacip should not be used by patients with:

• Hypercalcemia
• Metastatic calcification
• Hyperphosphatemia (unless occurring with hypoparathyroidism)
• Hypermagnesemia
• Vitamin D toxicity
• Hypersensitivity to vitamin D or its analogues

Possible Side Effects

Adverse reactions may include:

• Hypercalcemia
• Malaise, tiredness, weakness
• Nausea and vomiting
• Headache and dizziness
• Constipation or diarrhea
• Dry mouth
• Abdominal or gastrointestinal pain (e.g., heartburn)
• Heart palpitations
• Bone, muscle, or joint pain

Drug Interactions

Long-term use of anticonvulsants (such as phenytoin) may alter vitamin D and calcium metabolism, leading to metabolic bone disease, hypocalcemia, or seizures. Calcium levels should be monitored in patients on antiepileptic drugs.

Missed Dose

If a dose is missed, take it as soon as rememberer, unless it is nearly time for the next dose. Do not double the dose to compensate. Maintaining a consistent daily schedule helps prevent missed doses.

Overdose

Symptoms of overdose may include:

• High fever
• Elevated blood pressure
• Irregular heartbeat
• Severe stomach pain

Storage

Store at room temperature (59-77°F / 15-25°C) away from light, moisture, children, and pets. Do not use after the expiration date.

Disclaimer

This information is intended for general purposes only and does not cover all possible instructions, drug interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult a healthcare provider for personalized medical guidance. We disclaim liability for any errors or misuse of this information.