Common Use

The main component of Addyi is flibanserin - 100 mg. Flibanserin preferentially activates 5-HT1A receptors in the prefrontal cortex, demonstrating regional selectivity. It has been found to increase dopamine and norepinephrine levels while decreasing serotonin levels in the rat prefrontal cortex, actions mediated by the activation of the 5-HT1A receptor.

Dosage and Direction

Addyi is taken orally at a dosage of 100 mg once daily at bedtime for the treatment of hypoactive sexual desire disorder (HSDD). The onset of flibanserin's effect is typically observed after 4 weeks of treatment and is maintained throughout the treatment period. If no improvement in symptoms is observed after 4 weeks, discontinue use. Addyi is not indicated to enhance sexual performance and is not approved for use in postmenopausal women or men. It is specifically indicated for premenopausal women with acquired, generalized HSDD characterized by low sexual desire causing marked distress or interpersonal difficulty, not due to co-existing medical or psychiatric conditions, relationship issues, or medication effects.

Precautions

Consult your doctor or pharmacist before starting flibanserin, especially if you have allergies to this drug or other allergies. Avoid alcohol while taking Addyi, as it may cause dangerously low blood pressure. Do not use Addyi if you have:

• Low blood pressure
• A history of alcoholism or drug addiction
• Liver disease
• A history of depression or mental illness
• Current alcohol consumption

Some medications can cause dangerous effects when used with Addyi. Inform your doctor if you are using any of the following drugs: nefazodone, ciprofloxacin, clarithromycin, erythromycin, telithromycin, fluconazole, itraconazole, ketoconazole, posaconazole, boceprevir, telaprevir, conivaptan, diltiazem, verapamil, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

Flibanserin may impair cognitive or motor function. Avoid driving or operating machinery for at least 6 hours after taking the medication. Dizziness or low blood pressure may increase the risk of falls or accidents. It is unknown if flibanserin harms an unborn baby or passes into breast milk. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications

Do not consume alcohol with Addyi, as it can cause dangerous side effects. Avoid grapefruit and grapefruit juice, as they may interact with flibanserin. Do not use herbal supplements containing ginkgo biloba, resveratrol, or St. John's wort. Addyi is contraindicated for patients taking other medications for HSDD or drugs for high blood pressure. It is not approved for use by men or individuals under 18 years old.

Possible Side Effects

Seek emergency medical help if you experience signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Contact your doctor immediately if you feel very drowsy or light-headed. Common side effects of Addyi may include dizziness, nausea, fatigue, dry mouth, sleepiness, or trouble sleeping. Report any side effects to your doctor or pharmacist.

Drug Interactions

Taking Addyi with other drugs that cause drowsiness or lower blood pressure can worsen its effects. Consult your doctor before using Addyi with sleeping pills, narcotic pain medications, muscle relaxers, or drugs for anxiety, depression, or seizures. Inform your doctor about all medications you are taking, including cimetidine, ginkgo biloba, resveratrol, and St. John's wort. Your doctor may adjust your treatment plan if you are using antibiotics, antifungals, antivirals, heart or blood pressure medications, or HIV/AIDS drugs. This list is not exhaustive; other drugs may interact with flibanserin. Consult your doctor or pharmacist for further details.

Missed Dose

If you miss a dose of Addyi, skip it and take the next dose at bedtime the following day. Do not take it in the morning or double the dose to compensate.

Overdose

In case of an overdose, seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store Addyi at room temperature (20-25°C or 68-77°F), away from moisture and heat. Keep it out of reach of children and pets.

Disclaimer

The information provided here is general and does not cover all directions, possible drug interactions, or precautions. It should not be used for self-treatment or self-diagnosis. Specific instructions for a patient should be agreed upon with a healthcare provider. We are not responsible for any direct, indirect, or consequential damages resulting from the use of this information or from self-treatment.